Sildenafil, nifedipine and acetazolamide do not allow for blood flow through intrapulmonary arteriovenous anastomoses during exercise while breathing 100% oxygen

A Scripted Freelance Writer Writing Sample

Accordingly, the purpose of this study was to investigate the independent effects of sildenafil, nifedipine and acetazolamide on the regulation of Q ̇ IPAVA during exercise while breathing 100% O2. To this end, we studied nine healthy human subjects at rest and during submaximal exercise. This was performed while breathing room air and 100% O2 at base-line without any pharmacological intervention, with a single dose of sildenafil, with a single dose of nifedipine, and after acetazolamide administration. We hypothesized that if the hyperoxia-mediated reduction in Q ̇ IPAVA was regulated primarily by L-type calcium channels then oral nifedepine would allow for Q ̇ IPAVA during exercise while breathing 100% O2. Additionally, we hypothesized that if the hyperoxia-mediated reduction in Q ̇ IPAVA was regulated primarily through nitric oxide, then oral sildenafil would allow for Q ̇ IPAVA during exercise while breathing 100% O2. Lastly, we hypothesized that if the hyperoxia-mediated reduction in Q ̇ IPAVA was regulated primarily by non-L-type calcium channels then oral acetazolamide would allow for Q ̇ IPAVA during exercise while breathing 100% O2.

Subscribe for the latest in Content Marketing & Freelance Writing!


Jonathan F

Chicago, Illinois, United States •

I am a Medical Student at Rosalind Franklin University of Medicine and Science specializing in Podiatric Medicine and Surgery. I am also a freelance writer and blogger of all subjects with special interests in health, wellness, film, and music.

Customer Ratings 1
1 Customer Favorite
Power your marketing with great writing. – Start your 30-day free trial today! Start Free Trial

While you're here, have you tried Scripted lately?

Used to be a member, but moved on? Heard of it, but never signed up? The current iteration of Scripted will amaze you! Streamline your content writing efforts and build your own team of high-quality writers. It's all you need for content writing. Try it free today and meet your next favorite writer or writers!

Scripted’s talented community of freelance writers have a variety of expertise and specialties. While many of our customers hire writers to execute their content marketing strategy, our writers deliver high-quality content in many formats. You can find content writers, blog writers, ghostwriters, and SEO writers all with experience in your niche.